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Literature summary for 2.7.11.26 extracted from
- Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau (2009), J. Neurosci., 29, 14439-14450.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hippocampus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | - |
Mus musculus | ADP + protein tau phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen synthase kinase-3beta | - |
Mus musculus |
| GSK-3beta | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | GSK-3beta levels are elevated by about 80% in APP transgenic neuronal cultures | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inhibition of GSK-3beta abolishes Abeta-induced spine alterations | Mus musculus |
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