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Literature summary for 2.7.11.26 extracted from

  • Gimenez-Cassina, A.; Lim, F.; Cerrato, T.; Palomo, G.M.; Diaz-Nido, J.
    Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3 (2009), J. Biol. Chem., 284, 3001-3011.
    View publication on PubMed
Search for more literature for 2.7.11.26

Protein Variants

Protein Variants Comment Organism
K85R dead-kinase mutant of GSK-3beta Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LiCl complete inhibition at 2 mM Homo sapiens
SB-415286 complete inhibition at 0.005 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain stem
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Homo sapiens ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
 Homo sapiens
GSK-3beta isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction chronic inhibition of GSK-3 enhances glycolysis Mus musculus
physiological function mitochondrial hexokinase II is a promoter of neuronal survival under the regulation of GSK-3 Mus musculus