Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-bromo-indirubin-3'-oxime | selective and potent GSK3beta inhibitor | Rattus norvegicus | |
LiCl | lithium is a weak inhibitor of GSK3beta, lithium dose-dependently inhibits GSK3beta through the phosphorylation of serine 9 residue | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortical neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | - |
Rattus norvegicus | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Rattus norvegicus |
GSK3beta | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | GSK3beta regulates both tau phosphorylation and total tau levels through protein phosphatase-2A | Rattus norvegicus |