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Literature summary for 2.7.11.26 extracted from

  • Wen, Y.; Planel, E.; Herman, M.; Figueroa, H.Y.; Wang, L.; Liu, L.; Lau, L.F.; Yu, W.H.; Duff, K.E.
    Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing (2008), J. Neurosci., 28, 2624-2632.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
CP-681301 CP-681301 treatment reverses the inhibition of GSK3beta activity Mus musculus
additional information dephosphorylation at the inhibitory GSK3beta-Ser9 site activates the enzyme, GSK3beta activity increases with aging Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information cdk5 can negatively regulate GSK3beta activity through neuregulin/ErbB signaling, phosphorylation at the inhibitory GSK3beta-Ser9 site activates GSK3beta Mus musculus
p25 p25 overexpressing mice have reduced GSK3beta activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Mus musculus ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3beta
-
 Mus musculus
GSK3beta
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus