Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tau phosphorylation by TPKI/GSK3beta occurs rapidly in the hippocampus and its neighboring regions under a physiological learning situation of fear conditioning paradigm | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | involvement of tau and TPKI/GSK3beta phosphorylation in an early phase of memory formation in the hippocampus and amygdala, possibility that a dysregulation of tau phosphorylation may underlie memory impairment in incipient Alzheimer's disease | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6Njcl mice | - |
Mus musculus C57BL/6Njcl | - |
C57BL/6Njcl mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | entire amygdala or ventroposterior quadrant of cerebral hemisphere | Mus musculus | - |
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | phosphorylation at Ser9 | Mus musculus | ADP + protein tau phosphate | - |
? | |
ATP + protein tau | phosphorylation at Ser9 | Mus musculus C57BL/6Njcl | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPKI/GSK3beta | - |
Mus musculus |