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Literature summary for 2.7.11.26 extracted from

  • Fujio, J.; Hosono, H.; Ishiguro, K.; Ikegami, S.; Fujita, S.C.
    Tau phosphorylation in the mouse brain during aversive conditioning (2007), Neurochem. Int., 51, 200-208.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
additional information tau phosphorylation by TPKI/GSK3beta occurs rapidly in the hippocampus and its neighboring regions under a physiological learning situation of fear conditioning paradigm Mus musculus

Application

Application Comment Organism
medicine involvement of tau and TPKI/GSK3beta phosphorylation in an early phase of memory formation in the hippocampus and amygdala, possibility that a dysregulation of tau phosphorylation may underlie memory impairment in incipient Alzheimer's disease Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6Njcl mice
-
Mus musculus C57BL/6Njcl
-
 C57BL/6Njcl mice
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala entire amygdala or ventroposterior quadrant of cerebral hemisphere Mus musculus
-
brain
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau phosphorylation at Ser9 Mus musculus ADP + protein tau phosphate
-
 ?
ATP + protein tau phosphorylation at Ser9 Mus musculus C57BL/6Njcl ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
TPKI/GSK3beta
-
 Mus musculus