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Literature summary for 2.7.11.26 extracted from

  • Cho, J.H.; Johnson, G.V.
    Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ (2004), J. Biol. Chem., 279, 54716-54723.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of HA-tagged wild-type and mutant enzymes in CHO cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R96A site-directed mutagenesis of GSK3beta, the mutant shows reduced phosphorylation activity at primed epitopes and increased activity at unprimed epitopes of tau protein substrate compared to the wild-type GSK3beta Homo sapiens
S9A site-directed mutagenesis, mutant cannot be inhibited by phosphorylation at position 9 and is thus constitutively active Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation of GSK3beta at S9 inhibits the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
Homo sapiens 5874
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview ADP + O-phospho-[tau-protein]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of GSK3beta at S9 inhibits the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
Homo sapiens ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview Homo sapiens ADP + O-phospho-[tau-protein]
-
?
additional information GSK3beta catalyzes tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins, EC 2.7.11.1, in different tissues Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3 beta
-
Homo sapiens
GSK3beta
-
Homo sapiens
More see also EC 2.7.11.1 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens