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Literature summary for 2.7.11.26 extracted from
- tau-Tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau (2001), FEBS Lett., 492, 221-227.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Rattus norvegicus |
| medicine | - |
Bos taurus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
| mouse TTK cDNA isolated using amino acid sequences of purified bovine brain TTK | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
calculated from cDNA sequence | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | Mus musculus | - |
ADP + protein tau phosphate | - |
? |  |
| ATP + protein tau | Rattus norvegicus | - |
ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | Bos taurus | - |
ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | Rattus norvegicus Wistar | - |
ADP + protein tau phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Mus musculus | - |
mouse | - |
| Mus musculus | Q3UVR3 | mouse, brain TTK cDNA nucleotide sequence, same accession number in EMBL/DDBJ | - |
| Rattus norvegicus | - |
Wistar | - |
| Rattus norvegicus Wistar | - |
Wistar | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 2 isoenzymes, TPKI and TPKII | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| heart | - |
Mus musculus | - |
| muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | - |
Mus musculus | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | - |
Rattus norvegicus | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | - |
Bos taurus | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | - |
Rattus norvegicus Wistar | ADP + protein tau phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tau-tubulin kinase | - |
Rattus norvegicus |
| tau-tubulin kinase | - |
Bos taurus |
| TPKI/GSK-3beta | - |
Mus musculus |
| TTK | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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