Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | not activated by cyclic nucleotides cAMP and cGMP, calmodulin or phospholipide | Rattus norvegicus | |
tubulin | stimulates phosphorylation of tau under the condition of microtubile formation | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Rattus norvegicus | 5874 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | Rattus norvegicus | microtubule-associated protein | ADP + protein tau phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | microtubule-associated protein, enzyme can also phosphorylate human tau | Rattus norvegicus | ADP + protein tau phosphate | - |
? | |
ATP + protein tau | microtubule-associated protein | Rattus norvegicus | ADP + protein tau phosphate | - |
? |