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Literature summary for 2.7.11.26 extracted from

  • Ishiguro, K.; Ihara, Y.; Uchida, T.; Imahori, K.
    A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau (1988), J. Biochem., 104, 319-321.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information not activated by cyclic nucleotides cAMP and cGMP, calmodulin or phospholipide Rattus norvegicus
tubulin stimulates phosphorylation of tau under the condition of microtubile formation Rattus norvegicus

Application

Application Comment Organism
medicine brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
Rattus norvegicus 5874
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Rattus norvegicus microtubule-associated protein ADP + protein tau phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau microtubule-associated protein, enzyme can also phosphorylate human tau Rattus norvegicus ADP + protein tau phosphate
-
?
ATP + protein tau microtubule-associated protein Rattus norvegicus ADP + protein tau phosphate
-
?