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Literature summary for 2.7.11.23 extracted from

  • Donnio, L.M.; Lagarou, A.; Sueur, G.; Mari, P.O.; Giglia-Mari, G.
    CSB-dependent cyclin-dependent kinase 9 degradation and RNA polymerase II phosphorylation during transcription-coupled repair (2019), Mol. Cell. Biol., 39, e00225-18 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [RNA polymerase II] Homo sapiens the CDK9 subunit of positive transcription elongation factor b phosphorylates RNA polymerase II at its Ser-2 carboxy-terminal domain repeat ADP + phospho-[RNA polymerase II]
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50750
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MRC-5 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [RNA polymerase II] the CDK9 subunit of positive transcription elongation factor b phosphorylates RNA polymerase II at its Ser-2 carboxy-terminal domain repeat Homo sapiens ADP + phospho-[RNA polymerase II]
-
 ?
additional information during transcription after repair, UV irradiation induces a specific Ser-2 phosphorylation of the RNA polymerase II and this phosphorylation is Cockayne syndrome group B protein-dependent. The CDK9 subunit of positive transcription elongation factor b is not responsible for this phosphorylation but instead might play a nonenzymatic role in transcription restart after DNA repair Homo sapiens ?
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Synonyms

Synonyms Comment Organism
CDK9 subunit of positive transcription elongation factor b Homo sapiens
positive transcription elongation factor b
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 Homo sapiens