Literature summary for 2.7.11.23 extracted from

Duan, J.; Liu, Q.; Su, S.; Cha, J.; Zhou, Y.; Tang, R.; Liu, X.; Wang, Y.; Liu, Y.; He, Q.
The Neurospora RNA polymerase II kinase CTK negatively regulates catalase expression in a chromatin context-dependent manner (2020), Environ. Microbiol., 22, 76-90 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [RNA polymerase II carboxyl terminal domain]	Neurospora crassa	phosphorylation at Ser-2	ADP + phospho-[RNA polymerase II carboxyl terminal domain]	-	?
ATP + [RNA polymerase II carboxyl terminal domain]	Neurospora crassa 87-3	phosphorylation at Ser-2	ADP + phospho-[RNA polymerase II carboxyl terminal domain]	-	?

Organism

Organism	UniProt	Comment	Textmining
Neurospora crassa	-	-	-
Neurospora crassa 87-3	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [RNA polymerase II carboxyl terminal domain]	phosphorylation at Ser-2	Neurospora crassa	ADP + phospho-[RNA polymerase II carboxyl terminal domain]	-	?
ATP + [RNA polymerase II carboxyl terminal domain]	phosphorylation at Ser-2	Neurospora crassa 87-3	ADP + phospho-[RNA polymerase II carboxyl terminal domain]	-	?

Synonyms

Synonyms	Comment	Organism
CTK-1	catalytic subunit	Neurospora crassa
RNA Pol II CTD kinase	-	Neurospora crassa
RNA polymerase II carboxyl terminal domain kinase complex	-	Neurospora crassa
RNA polymerase II kinase	-	Neurospora crassa
RNAPII CTD kinase complex	-	Neurospora crassa

General Information

General Information	Comment	Organism
malfunction	deletion of enzyme complex components in Neurospora leads to high CAT-3 expression level and resistance to H2O2-induced reactive oxygen species stress. Subunit CTK-1 deletion leads to dramatic decreases of SET-2 recruitment and histone H3 K36me3 modification	Neurospora crassa
metabolism	the enzyme complex participates in the transcription elongation of cat-3 and is required for the regulation of the cat-3 and cat-1	Neurospora crassa

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Release 2023.1 (January 2023)