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Literature summary for 2.7.11.23 extracted from

  • Kanin, E.I.; Kipp, R.T.; Kung, C.; Slattery, M.; Viale, A.; Hahn, S.; Shokat, K.M.; Ansari, A.Z.
    Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis (2007), Proc. Natl. Acad. Sci. USA, 104, 5812-5817.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Protein Variants

Protein Variants Comment Organism
additional information a temperature-sensitive mutant and the analog-sensitive mutant of Kin28 is that upon heat inactivation, Kin28ts alleles are unable to retain protein interactions with other subunits of the TFIIH complex Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
1-NA-PP1 potent inhibitor of Kin28as allele kinase activity, Kin28as inhibition reduces transcript capping, overview, but inhibition of Kin28 does not inhibit transcription Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal domain Saccharomyces cerevisiae TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II ADP + phosphoylated RNA polymerase II C-terminal subunit
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA polymerase II C-terminal domain TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal domain Cdk7 phosphorylates the C-terminal domain, CTD, that consists of multiple YSPTSPS heptapeptide repeats, at Ser5 Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
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 ?

Synonyms

Synonyms Comment Organism
cdk7
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 Saccharomyces cerevisiae
Cdk7/Kin28
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 Saccharomyces cerevisiae
Kin28
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 Saccharomyces cerevisiae
TFIIH
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 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae