Literature summary for 2.7.11.23 extracted from

Youdell, M.L.; Kizer, K.O.; Kisseleva-Romanova, E.; Fuchs, S.M.; Duro, E.; Strahl, B.D.; Mellor, J.
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36 (2008), Mol. Cell. Biol., 28, 4915-4926.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + RNA polymerase II C-terminal domain	Saccharomyces cerevisiae	the SRI domain of Set2 interacts with the phosphorylated CTD of elongating RNAPII leading to methylation of the chromatin during transcription	ADP + phosphoylated RNA polymerase II C-terminal domain	-	?
additional information	Saccharomyces cerevisiae	Set2-catalyzed H3K36me2 does not require either Ctk1-dependent phosphorylation of RNA polymerase II or the presence of the phospho-C-terminal domain, CTD, interaction (SRI) domain of Set2 for methylation of histone H3 at lysine 36 promoting deacetylation of transcribed chromatin and repressing cryptic promoters within genes. By contrast, H3K36me3 requires Spt6, proline 38 on histone H3, the CTD of RNAPII, Ctk1, and the C-terminal SRI domain of Set2, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q03957	wild-type strain BY4741	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + RNA polymerase II C-terminal domain	-	Saccharomyces cerevisiae	ADP + phosphoylated RNA polymerase II C-terminal domain	-	?
ATP + RNA polymerase II C-terminal domain	the SRI domain of Set2 interacts with the phosphorylated CTD of elongating RNAPII leading to methylation of the chromatin during transcription	Saccharomyces cerevisiae	ADP + phosphoylated RNA polymerase II C-terminal domain	-	?
additional information	Set2-catalyzed H3K36me2 does not require either Ctk1-dependent phosphorylation of RNA polymerase II or the presence of the phospho-C-terminal domain, CTD, interaction (SRI) domain of Set2 for methylation of histone H3 at lysine 36 promoting deacetylation of transcribed chromatin and repressing cryptic promoters within genes. By contrast, H3K36me3 requires Spt6, proline 38 on histone H3, the CTD of RNAPII, Ctk1, and the C-terminal SRI domain of Set2, overview	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
Ctk1	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)