Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.23 extracted from

  • Sogaard, T.M.; Svejstrup, J.Q.
    Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator (2007), J. Biol. Chem., 282, 14113-14120.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Mediator stimulates the CTD kinase activity of TFIIH manyfold, immobilized holo-RNAPII can be separated into RNAPII and Mediator Saccharomyces cerevisiae
additional information mediator-induced stimulation of C-terminal domain phosphorylation with TFIIH and CTDK1 kinase Saccharomyces cerevisiae
Rsp5 stimulates CTD kinase activity Saccharomyces cerevisiae
Rsp5 protein the unrelated CTD-binding protein, Rsp5, is capable of stimulating this CTD kinase activity Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information immobilization of holo-RNAPII via Rbp2 inhibits CTD hyperphosphorylation Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal repeat domain Saccharomyces cerevisiae hyperphosphorylation, the Mediator complex associates with RNA polymerase II, RNAPII, at least partly via the RNAPII C-terminal repeat domain, CTD, whose phosphorylation is involved in triggering promoter clearance ADP + phosphoylated RNA polymerase II C-terminal repeat domain
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native TFIIK, and native CTD kinase 1 by a tandem affinity purification method Saccharomyces cerevisiae
TFIIK, CTDK1 by tandem affinity purification Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + holo-RNA polymerase II C-terminal domain phosphorylation by the serine 5-specific TFIIH complex, its kinase module TFIIK or by the C-terminal domain serine 2-specific kinase CTDK1 Saccharomyces cerevisiae ?
-
?
ATP + RNA polymerase II C-terminal repeat domain hyperphosphorylation, the Mediator complex associates with RNA polymerase II, RNAPII, at least partly via the RNAPII C-terminal repeat domain, CTD, whose phosphorylation is involved in triggering promoter clearance Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal repeat domain
-
?
ATP + RNA polymerase II C-terminal repeat domain i.e. RNAPII CTD, hyperphosphorylation, the target specificity of TFIIK and CTDK1 differm, TFIIK phosphorylates Ser5, while CTDK1 phosphorylates Ser2 Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal repeat domain
-
?
additional information enzyme-Mediator complex dissociation assay, overview Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
CTD kinase
-
Saccharomyces cerevisiae
CTDK1
-
Saccharomyces cerevisiae
CTDK1 kinase
-
Saccharomyces cerevisiae
TFIIH
-
Saccharomyces cerevisiae
TFIIK
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Saccharomyces cerevisiae
ATP ATP-dependent dissociation of holo-RNAPII by TFIIH Saccharomyces cerevisiae