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Literature summary for 2.7.11.23 extracted from

  • Tamrakar, S.; Kapasi, A.J.; Spector, D.H.
    Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7 (2005), J. Virol., 79, 15477-15493.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cyclin H required by Cdk7 Homo sapiens
cyclin T1 required by Cdk9 Homo sapiens
additional information infection with human cytomegalovirus increases Cdk7 and Cdk9 activities and phosphorylation levels of the large subunit of RNA polymerase II CTD Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
roscovitine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information Cdk9 localizes with the input viral DNA at early infection time, later aggregation of Cdk7, Cdk9, and S2-phosphorylated RNAP II CTD occurs, colocalized with IE1/IE2 proteins adjacent to promyelocytic leukemia protein oncogenic domains, overview Homo sapiens
-
-
nucleus Cdk7 and Cdk9 are distributed throughout the nuclei of infected cells Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [DNA-directed RNA polymerase] Homo sapiens
-
ADP + phospho-[DNA-directed RNA polymerase]
-
?
additional information Homo sapiens the cyclin-dependent kinase 7 and 9 are involved in processing of cytomegalovirus RNA in infected cells, enzyme inhibition results in changes in differential splicing and polyadenylation of viral immediate early and UL37 transcripts, overview, viral infection alters localization of RNA polymerase II ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast foreskin fibroblasts Homo sapiens
-
foreskin foreskin fibroblasts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [DNA-directed RNA polymerase]
-
Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
?
ATP + [DNA-directed RNA polymerase] hyperphosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit, e.g. at Ser2 and Ser5, by cyclin-dependent kinase 7 and 9, i.e. Cdk7 and Cdk9 Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
?
additional information the cyclin-dependent kinase 7 and 9 are involved in processing of cytomegalovirus RNA in infected cells, enzyme inhibition results in changes in differential splicing and polyadenylation of viral immediate early and UL37 transcripts, overview, viral infection alters localization of RNA polymerase II Homo sapiens ?
-
?
additional information cyclin-dependent kinase 7 and 9, i.e. Cdk7 and Cdk9, perform also the cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cdk7
-
Homo sapiens
CDK9
-
Homo sapiens
More see also EC 2.7.11.22 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens