Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin H | required by Cdk7 | Homo sapiens | |
cyclin T1 | required by Cdk9 | Homo sapiens | |
additional information | infection with human cytomegalovirus increases Cdk7 and Cdk9 activities and phosphorylation levels of the large subunit of RNA polymerase II CTD | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
roscovitine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | Cdk9 localizes with the input viral DNA at early infection time, later aggregation of Cdk7, Cdk9, and S2-phosphorylated RNAP II CTD occurs, colocalized with IE1/IE2 proteins adjacent to promyelocytic leukemia protein oncogenic domains, overview | Homo sapiens | - |
- |
nucleus | Cdk7 and Cdk9 are distributed throughout the nuclei of infected cells | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [DNA-directed RNA polymerase] | Homo sapiens | - |
ADP + phospho-[DNA-directed RNA polymerase] | - |
? | |
additional information | Homo sapiens | the cyclin-dependent kinase 7 and 9 are involved in processing of cytomegalovirus RNA in infected cells, enzyme inhibition results in changes in differential splicing and polyadenylation of viral immediate early and UL37 transcripts, overview, viral infection alters localization of RNA polymerase II | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | foreskin fibroblasts | Homo sapiens | - |
foreskin | foreskin fibroblasts | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [DNA-directed RNA polymerase] | - |
Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase] | - |
? | |
ATP + [DNA-directed RNA polymerase] | hyperphosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit, e.g. at Ser2 and Ser5, by cyclin-dependent kinase 7 and 9, i.e. Cdk7 and Cdk9 | Homo sapiens | ADP + phospho-[DNA-directed RNA polymerase] | - |
? | |
additional information | the cyclin-dependent kinase 7 and 9 are involved in processing of cytomegalovirus RNA in infected cells, enzyme inhibition results in changes in differential splicing and polyadenylation of viral immediate early and UL37 transcripts, overview, viral infection alters localization of RNA polymerase II | Homo sapiens | ? | - |
? | |
additional information | cyclin-dependent kinase 7 and 9, i.e. Cdk7 and Cdk9, perform also the cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cdk7 | - |
Homo sapiens |
CDK9 | - |
Homo sapiens |
More | see also EC 2.7.11.22 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |