Literature summary for 2.7.11.23 extracted from

Kong, S.E.; Kobor, M.S.; Krogan, N.J.; Somesh, B.P.; Sogaard, T.M.; Greenblatt, J.F.; Svejstrup, J.Q.
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator (2005), J. Biol. Chem., 280, 4299-4306.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Saccharomyces cerevisiae	5634	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	Saccharomyces cerevisiae	the enzyme preferentially phosphorylates RNA poylmerase II bound in a native ternary complex in opposite to the Fcp1 phosphatase preferably dephosphorylating free RNA poylmerase II, after complex disruption, at Ser5, not Ser2, of the CTD, the TFIIH TD kinase is involved in RNA poylmerase II activity regulation, mechanism, overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	several strains congenic with strain W303	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	the enzyme preferentially phosphorylates RNA poylmerase II bound in a native ternary complex in opposite to the Fcp1 phosphatase preferably dephosphorylating free RNA poylmerase II, after complex disruption, at Ser5, not Ser2, of the CTD, the TFIIH TD kinase is involved in RNA poylmerase II activity regulation, mechanism, overview	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	phosphorylation of the C-terminal domain CTD of the RNA polymerase II large subunit at Ser2 and Ser5	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?

Synonyms

Synonyms	Comment	Organism
TFIIH CTD kinase	-	Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)