Literature summary for 2.7.11.23 extracted from

Palancade, B.; Bensaude, O.
Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation (2003), Eur. J. Biochem., 270, 3859-3870.

Search for more literature for 2.7.11.23

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Drosophila melanogaster	5634	-
nucleus	-	Homo sapiens	5634	-
nucleus	-	Saccharomyces cerevisiae	5634	-
nucleus	-	Schizosaccharomyces pombe	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	Drosophila melanogaster	CTD phosphorylation and transcription cycle overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	Saccharomyces cerevisiae	CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	Schizosaccharomyces pombe	CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	Homo sapiens	the CTD of the RNA polymerase II is the target for numerous enzymes, including cell cycle-dependent kinases and phosphatases, thus phosphorylation of the CTD becomes a key event during mRNA metabolism and physiological regulation of transcription, and is affected by cell stress or embryonic development, CTD phosphorylation and transcription cycle overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?
additional information	Homo sapiens	phosphorylation of CTD is required to disrupt the interactions between unphosphorylated CTD and the mediator complex to form a holoenzyme of RNA polymerase II or with transcription factors to form a preinitiation complex of transcription, disruption of the interactions at elongation of transcription are required to assist the recruitment of pre-mRNA modification enzymes	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-
Homo sapiens	-	-	-
Saccharomyces cerevisiae	-	-	-
Schizosaccharomyces pombe	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	CTD phosphorylation and transcription cycle overview	Drosophila melanogaster	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview	Schizosaccharomyces pombe	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	the CTD of the RNA polymerase II is the target for numerous enzymes, including cell cycle-dependent kinases and phosphatases, thus phosphorylation of the CTD becomes a key event during mRNA metabolism and physiological regulation of transcription, and is affected by cell stress or embryonic development, CTD phosphorylation and transcription cycle overview	Homo sapiens	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, e.g. at Ser2 and Ser5, overview	Homo sapiens	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, e.g. at Ser5, overview	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, overview	Drosophila melanogaster	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, overview	Schizosaccharomyces pombe	ADP + phospho-[DNA-directed RNA polymerase]	-	?
additional information	phosphorylation of CTD is required to disrupt the interactions between unphosphorylated CTD and the mediator complex to form a holoenzyme of RNA polymerase II or with transcription factors to form a preinitiation complex of transcription, disruption of the interactions at elongation of transcription are required to assist the recruitment of pre-mRNA modification enzymes	Homo sapiens	?	-	?
additional information	cyclin-dependent kinase Cdk1, Cdk7, and Cdk9, EC 2.7.11.22, and by MAPK, EC 2.7.11.24, phosphorylating specific serine residues	Homo sapiens	?	-	?
additional information	the reaction is also in vitro performed by cyclin-dependent kinase Ctk1, and Bur1, EC 2.7.11.22, phosphorylating specific serine residues	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
Cdk1	-	Homo sapiens
cdk7	-	Homo sapiens
CDK9	-	Homo sapiens
CTD kinase	-	Drosophila melanogaster
CTD kinase	-	Homo sapiens
CTD kinase	-	Saccharomyces cerevisiae
CTD kinase	-	Schizosaccharomyces pombe
MAPK	-	Homo sapiens
More	see also EC 2.7.11.22 and EC 2.7.11.24	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Drosophila melanogaster
ATP	-	Homo sapiens
ATP	-	Saccharomyces cerevisiae
ATP	-	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)