Literature summary for 2.7.11.23 extracted from

Patturajan, M.; Conrad, N.K.; Bregman, D.B.; Corden, J.L.
Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation (1999), J. Biol. Chem., 274, 27823-27828.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]	Saccharomyces cerevisiae	deletion of the kinase subunit Ctk1 results in phosphorylation of serine in position 5 of the CTD repeat during logarithmic growth and eliminates the transient increase in CTD serine 2 phosphorylation during the diauxic shift	ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]	deletion of the kinase subunit Ctk1 results in phosphorylation of serine in position 5 of the CTD repeat during logarithmic growth and eliminates the transient increase in CTD serine 2 phosphorylation during the diauxic shift	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]	-	?

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Release 2023.1 (January 2023)