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Literature summary for 2.7.11.22 extracted from

  • Monnerat, S.; Almeida Costa, C.I.; Forkert, A.C.; Benz, C.; Hamilton, A.; Tetley, L.; Burchmore, R.; Novo, C.; Mottram, J.C.; Hammarton, T.C.
    Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei (2013), PLoS ONE, 8, e67327.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
CYC9
-
 Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
K358M inactive Trypanosoma brucei

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
 x * 86000, SDS-PAGE Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Trypanosoma brucei
-
 ADP + phosphorylated protein
-
 ?
ATP + a protein Trypanosoma brucei Lister 427
-
 ADP + phosphorylated protein
-
 ?
additional information Trypanosoma brucei cdc2-related kinase 12 autophosphorylates in vivo ?
-
 ?
additional information Trypanosoma brucei Lister 427 cdc2-related kinase 12 autophosphorylates in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-
Trypanosoma brucei Lister 427
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Trypanosoma brucei ADP + phosphorylated protein
-
 ?
ATP + a protein
-
 Trypanosoma brucei Lister 427 ADP + phosphorylated protein
-
 ?
additional information cdc2-related kinase 12 autophosphorylates in vivo Trypanosoma brucei ?
-
 ?
additional information cdc2-related kinase 12 autophosphorylates in vivo Trypanosoma brucei Lister 427 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 86000, SDS-PAGE Trypanosoma brucei

Synonyms

Synonyms Comment Organism
cdc2-related kinase 12
-
 Trypanosoma brucei
CRK12:CYC9 a cyclin-dependent kinase-cyclin complex Trypanosoma brucei

General Information

General Information Comment Organism
malfunction enzyme depletion results in enlargement of the flagellar pocket and defects in endocytosis Trypanosoma brucei
physiological function cdc2-related kinase 12 is an essential protein in bloodstream stage Trypanosoma brucei Trypanosoma brucei