Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.22 extracted from

  • Liang, K.; Gao, X.; Gilmore, J.M.; Florens, L.; Washburn, M.P.; Smith, E.; Shilatifard, A.
    Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing (2015), Mol. Cell. Biol., 35, 928-938.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + polymerase II C-terminal domain Homo sapiens
-
ADP + phosphorylated polymerase II C-terminal domain
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14004
-
-
Homo sapiens Q9NYV4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + polymerase II C-terminal domain
-
Homo sapiens ADP + phosphorylated polymerase II C-terminal domain
-
?

Synonyms

Synonyms Comment Organism
CDK12 isoform Homo sapiens
CDK13 isoform Homo sapiens

General Information

General Information Comment Organism
malfunction isoform CDK12 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing Homo sapiens
malfunction isoform CDK13 depletion leads to a loss of expression of RNA processing factors and to defects in RNA processing Homo sapiens
physiological function isoform CDK12 affects RNA processing through direct physical interactions with RNA processing factors and by regulating their expression Homo sapiens
physiological function isoform CDK13 affect RNA processing through direct physical interactions with RNA processing factors and by regulating their expression Homo sapiens