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Literature summary for 2.7.11.22 extracted from

  • Rovnak, J.; Brewster, C.D.; Quackenbush, S.L.
    Retroviral cyclin enhances cyclin-dependent kinase-8 activity (2012), J. Virol., 86, 5742-5751.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information interaction of RV-cyclin with protein phosphatase 2A, overview Homo sapiens
Protein phosphatase 2A PP2A, enhances CDK8 kinase activity in vitro for the RNA polymerase II carboxy-terminal domain but not for histone H3. PP2A enhancement of CDK8 is independent of RV-cyclin expression and likely plays a role in the normal regulation of CDK8 Homo sapiens
RV-cyclin retroviral cyclin from Walleye dermal sarcoma virus, enhances CDK8 kinase activity in vitro for RNA polymerase II carboxy-terminal domain and histone H3. It is specific for cdk8, no activation of Cdk7 or Cdk9. The majority of the RV-cyclin structure is comprised of a cyclin box fold, which is responsible for binding to cyclin-dependent kinase-8. Two-hybrid interaction analysis in Saccharomyces cerevisiae strain Y190 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of FLAG-CDK8 or kinase-deficient FLAG-CDK8 in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CDK8 is activated by autophosphorylation. protein phosphatase 2A regulates CDK8 autophosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cyclin H protein CDK8 Homo sapiens ADP + cyclin H phosphoprotein
-
 ?
ATP + E2F1 protein CDK8 Homo sapiens ADP + E2F1 phosphoprotein
-
 ?
ATP + histone H3 protein CDK8 Homo sapiens ADP + histone H3 phosphoprotein
-
 ?
ATP + Med13 protein CDK8 Homo sapiens ADP + Med13 phosphoprotein
-
 ?
ATP + RNA polymerase II carboxy-terminal domain CDK8 Homo sapiens ADP + phosphorylated RNA polymerase II carboxy-terminal domain
-
 ?
ATP + SMAD protein CDK8 Homo sapiens ADP + SMAD phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
CDK8
-
 Homo sapiens
cyclin-dependent kinase-8
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PP2A enhancement of CDK8 is independent of RV-cyclin expression and likely plays a role in the normal regulation of CDK8 Homo sapiens