Cloned (Comment) | Organism |
---|---|
expression of CDK2/cyclin A, CDK7/cyclin H, and CDK9/cyclin T in baculovirus-infected insect cells, and expression of CDK5/p25 in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | - |
Asteroidea | |
(1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | - |
Homo sapiens | |
(2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate | - |
Asteroidea | |
(2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate | - |
Homo sapiens | |
(2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | - |
Asteroidea | |
(2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | - |
Homo sapiens | |
(2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | - |
Asteroidea | |
(2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | - |
Homo sapiens | |
(3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]- purin-2-yl]pyrrolidin-3-ol | - |
Homo sapiens | |
(3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]-purin-2-yl]pyrrolidin-3-ol | - |
Asteroidea | |
(R)-roscovitine | - |
Asteroidea | |
(R)-roscovitine | - |
Homo sapiens | |
flavopiridol | - |
Asteroidea | |
flavopiridol | - |
Homo sapiens | |
additional information | inhibitor synthesis and screening, docking study, overview | Asteroidea | |
additional information | inhibitor synthesis and screening, docking study, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Asteroidea | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native CDK1/cyclin B from oocyte by affinity chromatography | Asteroidea |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
oocyte | - |
Asteroidea | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Homo sapiens |
CDK | - |
Asteroidea |
Cdk1 | - |
Asteroidea |
CDK2 | - |
Homo sapiens |
Cdk5 | - |
Homo sapiens |
cdk7 | - |
Homo sapiens |
CDK9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Asteroidea |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | |
0.00018 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate | |
0.00018 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate | |
0.00019 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | |
0.00021 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (R)-roscovitine | |
0.00023 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (R)-roscovitine | |
0.00027 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | |
0.00028 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (R)-roscovitine | |
0.00033 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (R)-roscovitine | |
0.00037 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | |
0.00037 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | |
0.00045 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]-purin-2-yl]pyrrolidin-3-ol | |
0.00045 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]- purin-2-yl]pyrrolidin-3-ol | |
0.00048 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | |
0.0006 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (2R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]propane-1,2-diol | |
0.00061 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | |
0.00061 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]- purin-2-yl]pyrrolidin-3-ol | |
0.00065 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (3R,5S)-5-(hydroxymethyl)-1-[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]- purin-2-yl]pyrrolidin-3-ol | |
0.00082 | - |
CDK5/p25, pH 7.5, 30°C | Homo sapiens | (2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | |
0.00087 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (1S,2R,3R)-3-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]cyclohexane-1,2-diol | |
0.00087 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate | |
0.00098 | - |
CDK2/cyclin A, pH 7.5, 30°C | Homo sapiens | (2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | |
0.00101 | - |
CDK9/cyclin T, pH 7.5, 30°C | Homo sapiens | (2S)-4-[[9-iso-propyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butane-1,2-diol | |
0.0014 | - |
CDK1/cyclin B, pH 7.5, 30°C | Asteroidea | (2R)-2-hydroxy-3-[[9-(propan-2-yl)-6-[[4-(pyridin-2-yl)benzyl]amino]-9H-purin-2-yl]amino]propyl L-valinate |