Literature summary for 2.7.11.22 extracted from

Sabo, A.; Lusic, M.; Cereseto, A.; Giacca, M.
Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription (2008), Mol. Cell. Biol., 28, 2201-2212.

Search for more literature for 2.7.11.22

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	acetylation markedly reduces both the kinase function and transcriptional activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50750	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
acetylation	cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + histone H1	-	Homo sapiens	ADP + phosphorylated histone H1	-	?

Synonyms

Synonyms	Comment	Organism
CDK9	-	Homo sapiens
cyclin-dependent kinase 9	part of the positive transcription elongation factor b	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
cyclin	-	Homo sapiens

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Release 2023.1 (January 2023)