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Literature summary for 2.7.11.22 extracted from

  • Fukasawa, K.
    P53, cyclin-dependent kinase and abnormal amplification of centrosomes (2008), Biochim. Biophys. Acta, 1786, 15-23.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
CDC25 phosphatase major activator of CDK2 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
p16(INK4a)
-
 Mus musculus
p21WAF1/CIP1 potent CDK inhibitor Mus musculus
p27Kip1
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Mus musculus 5813
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the CDK2-cyclin E complex is a inducer of S-phase entry and key factor for the initiation of centrosome duplication, that CDK4/6-cyclin D are the proteins that compensates for the loss of CDK2 in the initiation of centrosome duplication ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the CDK2-cyclin E complex is a inducer of S-phase entry and key factor for the initiation of centrosome duplication, that CDK4/6-cyclin D are the proteins that compensates for the loss of CDK2 in the initiation of centrosome duplication Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
cyclin E
-
 Mus musculus