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Literature summary for 2.7.11.22 extracted from
- Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity (2007), Steroids, 72, 202-209.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cyclin A | - |
Homo sapiens | |
| cyclin E | - |
Homo sapiens | |
| additional information | Cdk activating kinase | Homo sapiens | |
| progestin | - |
Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | cyclin A/Cdk2 has profound effects on progesterone receptor activity and may have clinical implications for patients receiving antiprogestin therapies, multifaceted role for Cdk2 in the regulation of progesterone receptor transcriptional activity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in HeLa cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | dominant active Cdk2 mutant, increased progesterone receptor activity in cells overexpressing the mutant | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cdk2 inhibitor II | - |
Homo sapiens | |
| p21 | - |
Homo sapiens | |
| p27 | - |
Homo sapiens | |
| progesterone | - |
Homo sapiens | |
| roscovitine | binds to the ATP binding pocket of Cdk2, preventing phosphate transfer from ATP to the protein substrate | Homo sapiens | |
| siRNA | knock down of Cdk2 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | Homo sapiens | - |
ADP + phosphorylated steroid histone H1 | - |
? | |
| ATP + progesterone receptor | Homo sapiens | cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 | ADP + phosphorylated progesterone receptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CREB-binding protein | - |
Homo sapiens | ADP + phosphorylated CREB-binding protein | - |
? | |
| ATP + estrogen receptor | Cdk2 phosphorylation at Ser104 and Ser106 | Homo sapiens | ADP + phosphorylated estrogen receptor | - |
? | |
| ATP + glucocorticoid receptor | - |
Homo sapiens | ADP + phosphorylated glucocorticoid receptor | - |
? | |
| ATP + glucocorticoid receptor | - |
Rattus norvegicus | ADP + phosphorylated glucocorticoid receptor | - |
? | |
| ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated steroid histone H1 | - |
? | |
| ATP + progesterone receptor | cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
| ATP + progesterone receptor | cyclin A2/Cdk2 phosphorylates progesterone receptor in vitro at Ser25, Ser162, Ser190, Ser213, Ser400, Thr 430, Ser554 and Ser676 | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
| ATP + steroid receptor coactivator-1 | - |
Homo sapiens | ADP + phosphorylated steroid receptor coactivator-1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclin A2/Cdk2 | - |
Homo sapiens |
| cyclin A2/Cdk2 | - |
Rattus norvegicus |
| cyclin dependent kinase 2 | - |
Homo sapiens |
| cyclin dependent kinase 2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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