Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.22 extracted from

  • Kanungo, J.; Li, B.S.; Goswami, M.; Zheng, Y.L.; Ramchandran, R.; Pant, H.C.
    Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5 (2007), Neurosci. Lett., 412, 233-238.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information zebrafish cdk5 is 96% identical to its human counterpart, Xenopus and most other vertebrate cdk5, the enzyme plays a crucial role in the development of the peripheral nervous system Danio rerio

Cloned(Commentary)

Cloned (Comment) Organism
-
Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
siRNA knockdown of cdk5, results in a reduction in primary sensory neurons of the trigeminal ganglia of the peripheral nervous system, 80% loss of cdk5 protein in 10 hpf embryos Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blastula 2.5 hpf Danio rerio
-
brain 24hpf embryos Danio rerio
-
embryo at 11.5 h of development, cdk5 transcripts are present in the neural plate at the domains where primary neurons begin to be specified Danio rerio
-
eye especially in the lens capsule of 24hpf embryos Danio rerio
-
muscle 24hpf embryos Danio rerio
-
spinal cord 24hpf embryos Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
Danio rerio ADP + phosphorylated histone H1
-
?

Synonyms

Synonyms Comment Organism
Cdk5
-
Danio rerio
cyclin-dependent kinase 5
-
Danio rerio