Any feedback?
Literature summary for 2.7.11.22 extracted from
- Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability (2006), Gene, 371, 1-6.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cdc25A | - |
Homo sapiens | |
| cyclin E | enhances Cdk activity, overexpression activates the DNA damage response in U2-OS osteogenic sarcoma cells | Homo sapiens | |
| E2F1 | - |
Homo sapiens | |
| additional information | Chk1 inhibition augments Cdk activity | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Cdk dysregulation in the generation of genomic instability, increased Cdk activity may critically reduce licensing of origins of DNA replication, drive re-replication, or mediate overexpression of checkpoint proteins, inducing deleterious cell cycle delay. These effects may fuel tumorigenesis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | dominant negative mutant of CDK2, induction delays S phase progression in many cell types, is not relieved by treatment with potent checkpoint inhibitor caffeine | Homo sapiens |
| additional information | yeast cells deficient in S phase Cdk activity acquire DNA damage, cdc7 mutants are unable to initiate DNA replication but have normal Cdk activity, induced double-strand break is promptly repaired | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cdk2DN | inhibition of Cdk2, induces phosphorylation of ataxia-telangiectasia mutated substrates | Homo sapiens | |
| additional information | inhibition of Cdk2 by inactivation of Cdc25 phosphatases | Homo sapiens | |
| p21 | induction of p21 by p53 leads to inhibition of Cdk2 and Cdk1 complexes | Homo sapiens | |
| Sic1 | Cdk inhibitor, double-strand break is not efficiently repaired | Saccharomyces cerevisiae | |
| siRNA | inhibition of Cdk2, induces phosphorylation of ataxia-telangiectasia mutated substrates | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + BRCA2 | Homo sapiens | phosphorylates at Ser3291, phosphorylation reaches maximal levels in G2/M | ADP + phosphorylated BRCA2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | primary diploid fibroblast | Homo sapiens | - |
| ovary cancer cell line | - |
Homo sapiens | - |
| U2-OS cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + BRCA2 | phosphorylates at Ser3291, phosphorylation reaches maximal levels in G2/M | Homo sapiens | ADP + phosphorylated BRCA2 | - |
? | |
| ATP + BRCA2 | phosphorylates at Ser3291, an event that disrupts association with RAD51 | Homo sapiens | ADP + phosphorylated BRCA2 | - |
? | |
| ATP + Cdc6 | - |
Homo sapiens | ADP + phosphorylated Cdc6 | - |
? | |
| ATP + DNA polymerase alpha | - |
Homo sapiens | ADP + phosphorylated DNA polymerase alpha | - |
? | |
| ATP + DNA polymerase sigma | - |
Homo sapiens | ADP + phosphorylated DNA polymerase sigma | - |
? | |
| ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
| ATP + Mcm3 | - |
Homo sapiens | ADP + phosphorylated Mcm3 | - |
? | |
| ATP + Mcm4 | - |
Homo sapiens | ADP + phosphorylated Mcm4 | - |
? | |
| ATP + Orc2 | - |
Homo sapiens | ADP + phosphorylated Orc2 | - |
? | |
| ATP + Orc6 | - |
Homo sapiens | ADP + phosphorylated Orc6 | - |
? | |
| ATP + replication factor C | - |
Homo sapiens | ADP + phosphorylated replication factor C | - |
? | |
| ATP + retinoblastoma protein | - |
Homo sapiens | ADP + phosphorylated retinoblastoma protein | - |
? | |
| additional information | Cdk activity is required to fire origins of DNA replication and to prevent 'licensing' (establishing the competence) of additional origins after replication initiation | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDK | - |
Saccharomyces cerevisiae |
| Cdk 2 | - |
Homo sapiens |
| cdk7 | - |
Saccharomyces cerevisiae |
| cyclin-dependent kinase | - |
Homo sapiens |
| cyclin-dependent kinase | - |
Saccharomyces cerevisiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
