Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin A | cyclin A/Cdk2 activity selectively increases during the early stages of etoposide-induced apoptosis | Homo sapiens | |
etoposide | activity of Cdk2 selectively increases after 6-9 h and then continues to increase over the 24 h time course of etopside treatment | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | Cdk2 activity is involved in the mitochondrial translocation of Bax, which plays an important role in the mitochondrial membrane permeability transition during apoptotic progression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HeLa cells co-transfected with pCMV-GFP, pCMV-Cyclin A, mutant pCMV-Cdk2-dn or pCMV-p21WAF1/CIP1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | dominant negative mutant Cdk2-dn, overexpression efficiently prevents etoposide-induced apoptotic cell death | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p21WAF1/CIP1 | specific Cdk inhibitor, efficiently prevents etoposide-induced apoptotic cell death | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | upregulated cyclin A/Cdk2 activity precedes the proteolytic cleavage of PARP and is correlated with mitochondrial translocation of Bax and loss of mitochondrial transmembrane potential during etoposide-induced apoptosis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK2 | - |
Homo sapiens |
cyclin A-dependent protein kinase 2 | - |
Homo sapiens |