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Literature summary for 2.7.11.22 extracted from

  • Lim, J.T.; Mansukhani, M.; Weinstein, I.B.
    Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells (2005), Proc. Natl. Acad. Sci. USA, 102, 5156-5161.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged CDK6 in 293T cells, stable overexpression of CDK6 in LNCaP cells leads to altered cell colony formation and stimulation of cell growth Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyclin D1 inhibits the association and activation of androgen receptor by CDK6 Homo sapiens
p16Ink4a inhibits the association and activation of androgen receptor by CDK6 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
-
 Homo sapiens 785
-
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CDK6/cyclin D1 enhances the transition of cells through the G1 phase of the cell cycle, CDK6 without bound cyclin D1 associates with the androgen receptor AR and enhances, independently of its kinase activity, its transcriptional activity in presence of dihydrotestosterone in prostate cancer cells, this stimulation is highly exaggerated with AR mutant T877A found in prostate cancer, thus CDK6 is probably important for prostate cancer development, CDK6 is no essential for stimulation of AR, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CDK6/cyclin D1 enhances the transition of cells through the G1 phase of the cell cycle, CDK6 without bound cyclin D1 associates with the androgen receptor AR and enhances, independently of its kinase activity, its transcriptional activity in presence of dihydrotestosterone in prostate cancer cells, this stimulation is highly exaggerated with AR mutant T877A found in prostate cancer, thus CDK6 is probably important for prostate cancer development, CDK6 is no essential for stimulation of AR, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cdk6
-
 Homo sapiens
cyclin-dependent kinase 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin D1 regulatory subunit of CDK6, activates Homo sapiens