Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p25 | interacts with CDK5 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-roscovitine | - |
Homo sapiens | |
alsterpaullone | - |
Homo sapiens | |
aminopurvalanol | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CDKs are cell cycle-related enzymes, CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native and active CDK1 and CDK2 from NT2 cells by affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
NTERA-2 cell | teratocarcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
additional information | CDKs are cell cycle-related enzymes, CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk1 | - |
Homo sapiens |
CDK2 | - |
Homo sapiens |
Cdk5 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cyclin B | regulatory subunit of CDK1 | Homo sapiens |