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Literature summary for 2.7.11.22 extracted from

  • Gompel, M.; Soulie, C.; Ceballos-Picot, I.; Meijer, L.
    Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation (2004), Neurosignals, 13, 134-143.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
p25 interacts with CDK5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)-roscovitine
-
Homo sapiens
alsterpaullone
-
Homo sapiens
aminopurvalanol
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CDKs are cell cycle-related enzymes, CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native and active CDK1 and CDK2 from NT2 cells by affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview Homo sapiens
-
neuron
-
Homo sapiens
-
NTERA-2 cell teratocarcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
Homo sapiens ADP + phosphorylated histone H1
-
?
additional information CDKs are cell cycle-related enzymes, CDK5 activity increases 1.6fold within 5 weeks during neuronal cell differentiation induced by retinoic acid, while the activity of CDK1 and CDK2 decreases by 14.4fold, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Cdk1
-
Homo sapiens
CDK2
-
Homo sapiens
Cdk5
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
cyclin B regulatory subunit of CDK1 Homo sapiens