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Literature summary for 2.7.11.22 extracted from

  • Rideout, H.J.; Wang, Q.; Park, D.S.; Stefanis, L.
    Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition (2003), J. Neurosci., 23, 1237-1245.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information the proteasomal inhibitor lactacystin induces the Cdk-dependent phosphorylation of the retinoblastoma protein Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression of dominant negative mutants of Cdks or of Cdk inhibitors p16 and p27 can protect cells against lactcystin-induced cell death Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
flavopiridol
-
 Rattus norvegicus
p16
-
 Rattus norvegicus
p27
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + retinoblastoma protein Rattus norvegicus i.e. Rb protein ADP + phosphorylated retinoblastoma protein
-
 ?
additional information Rattus norvegicus cyclin-dependent kinase activity is required for apoptotic death involving the retinoblastoma protein but not inclusion formation in cortical neurons after proteasomal inhibition, Cdk2, Cdk4, and Cdk6 promote the apoptosis induced by lactacystin and other proteasome inhibitors, expression of a defective retinoblastoma protein is neuroprotective ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron cortical Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + retinoblastoma protein i.e. Rb protein Rattus norvegicus ADP + phosphorylated retinoblastoma protein
-
 ?
additional information cyclin-dependent kinase activity is required for apoptotic death involving the retinoblastoma protein but not inclusion formation in cortical neurons after proteasomal inhibition, Cdk2, Cdk4, and Cdk6 promote the apoptosis induced by lactacystin and other proteasome inhibitors, expression of a defective retinoblastoma protein is neuroprotective Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Rattus norvegicus
CDK4
-
 Rattus norvegicus
cdk6
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus