Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CDK2 is activated by phosphorylation and cyclin binding | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
in vitro transcription and translation of CDK2 in rabbit reticulocyte lysate, expression of HA-tagged wild-type and mutant CDK2 in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T160A | site-directed mutagenesis of CDK2, phosphorylation site mutant, the mutant is activated upon binding of cyclin E | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | constitutitve activation of CDK2-cyclin E leads to G1/S deregulation and tumor progression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CDK2 is activated by phosphorylation at Thr160 and cyclin binding | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated histone H1 | - |
? | |
additional information | constitutitve activation of CDK2-cyclin E leads to G1/S deregulation and tumor progression | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK2 | - |
Homo sapiens |
cyclin-dependent kinase 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cyclin A | competes with cyclin E isoforms | Homo sapiens | |
cyclin E | dependent on, high expression level in breast cancer cells, activating low molecular weight forms L, T1, and T2 of the cyclin E are expressed in breast cancer, modeling of CDK2 activation by cyclin E, overview | Homo sapiens |