Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p21 protein | i.e. Cip1 or Waf1, a Cdk-inhibitor | Homo sapiens | |
p21 protein | i.e. Cip1 or Waf1, a Cdk-inhibitor | Xenopus laevis | |
roscovitine | - |
Homo sapiens | |
roscovitine | - |
Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdc20 | Homo sapiens | Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells | ADP + phosphorylated Cdc20 | - |
? | |
ATP + Cdc20 | Xenopus laevis | substrate of Cdk1, rather than of Cdk2 | ADP + phosphorylated Cdc20 | - |
? | |
additional information | Xenopus laevis | Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview | ? | - |
? | |
additional information | Homo sapiens | Cdks are cell cycle regulating enzymes, the spindle checkpoint requires cyclin-dependent kinase activity, regulation overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Xenopus laevis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
egg | in cytostatic-arrested M-phase | Xenopus laevis | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdc20 | Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells | Homo sapiens | ADP + phosphorylated Cdc20 | - |
? | |
ATP + Cdc20 | substrate of Cdk1, rather than of Cdk2 | Xenopus laevis | ADP + phosphorylated Cdc20 | - |
? | |
ATP + Cdc20 | in vitro substrate of Cdk1 and Cdk2 | Homo sapiens | ADP + phosphorylated Cdc20 | - |
? | |
ATP + Cdc20 | in vitro substrate of Cdk1 and Cdk2 | Xenopus laevis | ADP + phosphorylated Cdc20 | - |
? | |
additional information | Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview | Xenopus laevis | ? | - |
? | |
additional information | Cdks are cell cycle regulating enzymes, the spindle checkpoint requires cyclin-dependent kinase activity, regulation overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Homo sapiens |
CDK | - |
Xenopus laevis |
Cdk1 | - |
Homo sapiens |
Cdk1 | - |
Xenopus laevis |
CDK2 | - |
Homo sapiens |
CDK2 | - |
Xenopus laevis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | - |
assay at | Homo sapiens |
23 | - |
assay at | Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Xenopus laevis | |
cyclin B | stabilizing regulatory subunit of Cdk1 | Homo sapiens | |
cyclin B | stabilizing regulatory subunit of Cdk1 | Xenopus laevis | |
cyclin E | stabilizing regulatory subunit of Cdk2 | Homo sapiens | |
cyclin E | stabilizing regulatory subunit of Cdk2 | Xenopus laevis |