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Literature summary for 2.7.11.22 extracted from

  • D'Angiolella, V.; Mari, C.; Nocera, D.; Rametti, L.; Grieco, D.
    The spindle checkpoint requires cyclin-dependent kinase activity (2003), Genes Dev., 17, 2520-2525.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
p21 protein i.e. Cip1 or Waf1, a Cdk-inhibitor Homo sapiens
p21 protein i.e. Cip1 or Waf1, a Cdk-inhibitor Xenopus laevis
roscovitine
-
Homo sapiens
roscovitine
-
Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Cdc20 Homo sapiens Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells ADP + phosphorylated Cdc20
-
?
ATP + Cdc20 Xenopus laevis substrate of Cdk1, rather than of Cdk2 ADP + phosphorylated Cdc20
-
?
additional information Xenopus laevis Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview ?
-
?
additional information Homo sapiens Cdks are cell cycle regulating enzymes, the spindle checkpoint requires cyclin-dependent kinase activity, regulation overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg in cytostatic-arrested M-phase Xenopus laevis
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cdc20 Cdk phosphorylation affects interaction of Cdc20 with Mad2 and the anaphase-promoting complex-cyclosome in HeLa cells Homo sapiens ADP + phosphorylated Cdc20
-
?
ATP + Cdc20 substrate of Cdk1, rather than of Cdk2 Xenopus laevis ADP + phosphorylated Cdc20
-
?
ATP + Cdc20 in vitro substrate of Cdk1 and Cdk2 Homo sapiens ADP + phosphorylated Cdc20
-
?
ATP + Cdc20 in vitro substrate of Cdk1 and Cdk2 Xenopus laevis ADP + phosphorylated Cdc20
-
?
additional information Cdks are cell cycle regulating enzymes, Cdk1 phosphorylates the anaphase-promoting complex-cyclosome during mitosis, which is a prerequisite for its activity but reduces the anaphase-promoting complex-cyclosome interaction with Cdc20 involving Mad2, the spindle checkpoint requires cyclin-dependent kinase activity, inhibition of Cdk overrides checkpoint-dependent arrest in eggs increasing the interaction of the anaphase-promoting complex-cyclosome with Cdc20, regulation overview Xenopus laevis ?
-
?
additional information Cdks are cell cycle regulating enzymes, the spindle checkpoint requires cyclin-dependent kinase activity, regulation overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CDK
-
Homo sapiens
CDK
-
Xenopus laevis
Cdk1
-
Homo sapiens
Cdk1
-
Xenopus laevis
CDK2
-
Homo sapiens
CDK2
-
Xenopus laevis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
assay at Homo sapiens
23
-
assay at Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Xenopus laevis
cyclin B stabilizing regulatory subunit of Cdk1 Homo sapiens
cyclin B stabilizing regulatory subunit of Cdk1 Xenopus laevis
cyclin E stabilizing regulatory subunit of Cdk2 Homo sapiens
cyclin E stabilizing regulatory subunit of Cdk2 Xenopus laevis