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Literature summary for 2.7.11.22 extracted from

  • Zong, H.; Li, Z.; Liu, L.; Hong, Y.; Yun, X.; Jiang, J.; Chi, Y.; Wang, H.; Shen, X.; Hu, Y.; Niu, Z.; Gu, J.
    Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity (2005), FEBS Lett., 579, 3579-3588.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
p58 regulatory subunit of CDK11 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of CDK11p58 and HBO1 in the two-hydrid system using Saccharomyces cerevisiae strain EGY48, overexpression of GST- or HA-tagged CDK11p58 in HeLa and COS-1 cells leads to increased histone acetyltransferase HBO1 activity towards free histones Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus CDK11p58 and histone acetyltransferase HBO1 colocalize in the nucleus Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 x * 58000, CDK11p58 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo, CDK11p58 acts as a regulator of HBO1 activity in eukaryotic transcription ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver fetal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo, CDK11p58 acts as a regulator of HBO1 activity in eukaryotic transcription Homo sapiens ?
-
 ?
additional information CDK11p58 interacts with the histone acetyltransferase HBO1 in vitro and in vivo Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 58000, CDK11p58 Homo sapiens

Synonyms

Synonyms Comment Organism
cyclin-dependent kinase 11p58
-
 Homo sapiens
More the enzyme belongs to the PITSLRE kinase family Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens