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Literature summary for 2.7.11.22 extracted from

  • Andres, V.
    Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential (2004), Cardiovasc. Res., 63, 11-21.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
additional information CDKs are activated by phosphorylation Mus musculus
additional information CDKs are activated by phosphorylation Homo sapiens
additional information CDKs are activated by phosphorylation Rattus norvegicus

Application

Application Comment Organism
medicine the CDK-cyclins are targets for pharmacological and gene therapy strategies for the treatment of cardiovascular disease Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of CDK-null mutant mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Homo sapiens
CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Mus musculus
CDK inhibitory proteins members of the family of CDK inhibitory proteins, e.g. INK4 proteins, overview, CKIs may play a role as regulators in neointimal hyperplasia Rattus norvegicus
CVT-313 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM, for CDK2 0.0005 mM, and for CDK4 0.215 mM Rattus norvegicus
flavopiridol inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM, for CDK2 0.0001 mM, for CDK4 0.000065 mM, for CDK6 0.00006 mM, and for CDK7 0.00011-0.0003 mM Rattus norvegicus
INK4 proteins inhibit CDK4 Homo sapiens
INK4 proteins inhibit CDK4 Mus musculus
INK4 proteins inhibit CDK4 Rattus norvegicus
additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Homo sapiens
additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Mus musculus
additional information physiological effects of CDK inhibition, overview, CDKs are deactivated by dephosphorylation, protein p27Kip1 mediates CDK2 inhibition Rattus norvegicus
p15Ink4b INK4 protein Homo sapiens
p15Ink4b INK4 protein Mus musculus
p15Ink4b INK4 protein Rattus norvegicus
p16Ink4a INK4 protein Homo sapiens
p16Ink4a INK4 protein Mus musculus
p16Ink4a INK4 protein Rattus norvegicus
p18Ink4c INK4 protein Homo sapiens
p18Ink4c INK4 protein Mus musculus
p18Ink4c INK4 protein Rattus norvegicus
p19Ink4d INK4 protein Homo sapiens
p19Ink4d INK4 protein Mus musculus
p19Ink4d INK4 protein Rattus norvegicus
simvastatin inhibition of CDK2 Homo sapiens
simvastatin inhibition of CDK2 Mus musculus
simvastatin inhibition of CDK2 Rattus norvegicus
tranilast inhibition of CDK2 and CDK4 Homo sapiens
tranilast inhibition of CDK2 and CDK4 Mus musculus
tranilast inhibition of CDK2 and CDK4 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pocket protein p107 Mus musculus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 Homo sapiens hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 Rattus norvegicus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p130 Mus musculus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 Homo sapiens hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 Rattus norvegicus hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated pocket protein 130
-
 ?
ATP + retinoblastoma protein Mus musculus i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein Homo sapiens i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein Rattus norvegicus i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis ADP + phosphorylated retinoblastoma protein
-
 ?
additional information Mus musculus CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?
additional information Homo sapiens CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?
additional information Rattus norvegicus CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CDK is regulated by de-/phosphorylation Mus musculus
phosphoprotein CDK is regulated by de-/phosphorylation Homo sapiens
phosphoprotein CDK is regulated by de-/phosphorylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Mus musculus
-
keratinocyte
-
 Homo sapiens
-
keratinocyte
-
 Rattus norvegicus
-
additional information different CDK-cyclins are orderly activated at specific phases of the cell cycle Homo sapiens
-
vascular cell
-
 Mus musculus
-
vascular cell
-
 Homo sapiens
-
vascular cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p107 hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated pocket protein 107
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated pocket protein 130
-
 ?
ATP + pocket protein p130 hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated pocket protein 130
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Mus musculus ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis Rattus norvegicus ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Mus musculus ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Homo sapiens ADP + phosphorylated retinoblastoma protein
-
 ?
ATP + retinoblastoma protein i.e. Rb protein, hyperphosphorylation by CDK/cyclin Rattus norvegicus ADP + phosphorylated retinoblastoma protein
-
 ?
additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Mus musculus ?
-
 ?
additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Homo sapiens ?
-
 ?
additional information CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK
-
 Mus musculus
CDK
-
 Homo sapiens
CDK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus
cyclin regulatory subunit of CDK Mus musculus
cyclin regulatory subunit of CDK Homo sapiens
cyclin regulatory subunit of CDK Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
 IC50 for CDK6 0.00006 mM Rattus norvegicus flavopiridol
0.000065
-
 IC50 for CDK4 0.000065 mM Rattus norvegicus flavopiridol
0.0001
-
 IC50 for CDK2 0.0001 mM Rattus norvegicus flavopiridol
0.00011 0.0003 IC50 for CDK7 0.00011-0.0003 mM Rattus norvegicus flavopiridol
0.0005
-
 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.0005 mM Rattus norvegicus flavopiridol
0.0005
-
 IC50 for CDK2 0.0005 mM Rattus norvegicus CVT-313
0.004
-
 inhibitor used in treatment of neointimal hyperplasia, IC50 for CDK1 is 0.004 mM Rattus norvegicus CVT-313
0.215
-
 IC50 for CDK4 0.215 mM Rattus norvegicus CVT-313