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Literature summary for 2.7.11.22 extracted from

  • Yang, L.; MacLellan, W.R.; Han, Z.; Weiss, J.N.; Qu, Z.
    Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle (2004), Biophys. J., 86, 3432-3443.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information CDK is phosphorylated by a CDK-activating kinase, positive feedback by Cdc25, Wee1, and CAK is involved in CDK regulation eukaryota

Inhibitors

Inhibitors Comment Organism Structure
additional information negative feedback regulation mechanism via reduced stability, CDK-cyclin oscillates during the cell cycle, overview eukaryota

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle, mathematical modeling of the enzyme complex behaviour, calculation of kinetics and dynamics, overview eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information eukaryota multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle, determination of the importance of phosphorylations of regulatory proteins in the cell cycle and biological network, CDK regulation involving positive feedback by Cdc25, Wee1, and CAK, mathematical modeling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CDK is phosphorylated by a CDK-activating kinase eukaryota

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle, determination of the importance of phosphorylations of regulatory proteins in the cell cycle and biological network, CDK regulation involving positive feedback by Cdc25, Wee1, and CAK, mathematical modeling, overview eukaryota ?
-
 ?

Synonyms

Synonyms Comment Organism
CDK
-
 eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP
-
 eukaryota
cyclin active CDK-cyclin oscillates during the cell cycle eukaryota