Protein Variants | Comment | Organism |
---|---|---|
additional information | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | low activity | Mus musculus | 5829 | - |
cytosol | low activity | Homo sapiens | 5829 | - |
membrane | mainly | Mus musculus | 16020 | - |
membrane | mainly | Homo sapiens | 16020 | - |
microtubule | - |
Mus musculus | 5874 | - |
microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Homo sapiens | - |
ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | Mus musculus | activity in organisms with mutated APP and tau, not in wild-type, overview | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Mus musculus | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits | ? | - |
? | |
additional information | Homo sapiens | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | distribution in brain regions, overview | Mus musculus | - |
brain | distribution in brain regions, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | activity in organisms with mutated APP and tau, not in wild-type, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of mutants leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of mutants leads to age-dependent memory deficits | Mus musculus | ? | - |
? | |
additional information | naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering from Alzheimer's disease leads to age-dependent memory deficits | Homo sapiens | ? | - |
? | |
additional information | cdk5 catalyzes tau phosphorylation in brain, but cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22, in different tissues | Mus musculus | ? | - |
? | |
additional information | cdk5 catalyzes tau phosphorylation in brain, but cyclin-dependent phosphorylation of other proteins, EC 2.7.11.22, in different tissues | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclin-dependent kinase 5 | - |
Mus musculus |
cyclin-dependent kinase 5 | - |
Homo sapiens |
glycogen synthase kinase-3alphabeta | - |
Mus musculus |
More | see also EC 2.7.11.1 and EC 2.7.11.22 | Mus musculus |
More | see also EC 2.7.11.26 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |