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Literature summary for 2.7.11.22 extracted from
- Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules (2003), J. Biol. Chem., 278, 10506-10515.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p35 | tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro | Mus musculus | |
| p39 | tightly bound neuronal activators of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro, p39 is the activator activator in vivo | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a cdk-deficient mouse mutant lacks tau phosphorylation activity | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | Mus musculus | cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26 | ADP + O-phospho -[tau-protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | developing postnatal and embryonic | Mus musculus | - |
| brain stem | - |
Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| cerebral cortex | - |
Mus musculus | - |
| additional information | expression pattern during brain development | Mus musculus | - |
| spinal cord | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | preferred substrate of cdk5 associated with p35 | Mus musculus | ADP + phosphorylated histone H1 | - |
? | |
| ATP + [tau-protein] | cdk5 substrate in brain, cdk5 associated with p39, tau is a microtubule-associated and developmentally regulated protein involved in axonal development in neurons, tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules, reaction of EC 2.7.11.26 | Mus musculus | ADP + O-phospho -[tau-protein] | - |
? | |
| ATP + [tau-protein] | preferred substrate of cdk5 associated with p39, recombinant bacterially expressed human tau protein as substrate, phosphorylation at Ser202 and Thr205, reaction of EC 2.7.11.26 | Mus musculus | ADP + O-phospho -[tau-protein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Mus musculus |
| cyclin-dependent kinase 5/p39 | - |
Mus musculus |
| More | see also EC 2.7.11.26 | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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