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Literature summary for 2.7.11.22 extracted from

  • Akoulitchev, S.; Reinberg, D.
    The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7 (1998), Genes Dev., 12, 3541-3550.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens TFIIH is a multisubunit complex, containing ATPase, helicases, and kinase subunit of TFIIH. In mitosis the CDK7 subunit of TFIIH and the largest subunit of RNAPII become hyperphosphorylated. MPF-induced phosphorylation of CDK7 results in inhibition of the TFIIH-associated kinase and transcription activities ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P50613
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TFIIH is a multisubunit complex, containing ATPase, helicases, and kinase subunit of TFIIH. In mitosis the CDK7 subunit of TFIIH and the largest subunit of RNAPII become hyperphosphorylated. MPF-induced phosphorylation of CDK7 results in inhibition of the TFIIH-associated kinase and transcription activities Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
cell division protein kinase 7
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Homo sapiens