Literature summary for 2.7.11.22 extracted from

Gu, Y.; Rosenblatt, J.; Morgan, D.O.
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 (1992), EMBO J., 11, 3995-4005.

Search for more literature for 2.7.11.22

Cloned(Commentary)

Cloned (Comment)	Organism
site-directed mutant proteins, expressed by transient transfection of COS cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P24941	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	two major phosphorylation sites are Tyr15 and Thr160. Additional phosphorylation probably occurs on Thr14. Phosphorylation at Thr160 is required for kinase activity. Phosphorylation at Thr14 and Tyr15 is inhibitory. CDK2 phosphorylation on Thr160 increases during S phase and G2, when CDK2 is most active. Phosphorylation on the inhibitory sites Thr14 and Tyr15 is also maximal during S phase and G2	Homo sapiens

Synonyms

Synonyms	Comment	Organism
cell division protein kinase 2	-	Homo sapiens

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Release 2023.1 (January 2023)