Literature summary for 2.7.11.22 extracted from

Krek, W.; Nigg, E.A.
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites (1991), EMBO J., 10, 305-316.

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Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	P13863	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	catalytic subunit, p34cdc2, of cdc2 kinase is controlled by phosphorylation--dephosphorylation reactions. Three phosphorylation sites are identified as Thr14, Tyr15 and Ser277. Phosphorylation of all four sites is cell cycle regulated. Thr14 and Tyr15 are phosphorylated maximally during G2 phase but dephosphorylated abruptly at the G2/M transition, concomitant with activation of p34cdc2 kinase. Phosphorylation of Thr14 and/or Tyr15 inhibits p34cdc2 kinase activity, in line with the location of these residues within the putative ATP binding site of the kinase. During M phase, p34cdc2 is also phosphorylated, but phosphorylation occurs on a Thr residue distinct from Thr14. Finally, phosphorylation of Ser277 peaks during G1 phase and drops markedly as cells progress through S phase	Gallus gallus

Synonyms

Synonyms	Comment	Organism
cell division control protein 2 homolog	-	Gallus gallus

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Release 2023.1 (January 2023)