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Literature summary for 2.7.11.21 extracted from
- Schistosoma mansoni Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction (2010), Int. J. Parasitol., 40, 1075-1086.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of SmPlk1 requires phosphorylation of the conserved threonine residue Thr182 | Schistosoma mansoni |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential new target against schistosomiasis | Schistosoma mansoni |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pDrive cloning vector for sequencing, into the pCR2.1-TOPO and V5His-tagged pcDNA3.1 expression vectors | Schistosoma mansoni |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| SmPlk1DK | dead kinase version of SmPlk1, obtained by replacing the D166FG168 active motif by a D166NA168 inactive motif | Schistosoma mansoni |
| SmPlk1T182D | constitutively active mutant | Schistosoma mansoni |
| SmPlk1T182D-DK | double mutant | Schistosoma mansoni |
| SmPlk1T182V | inactive mutant | Schistosoma mansoni |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BI2536 | - |
Schistosoma mansoni |  |
| GW843682X | - |
Schistosoma mansoni | |
| LY294002 | - |
Schistosoma mansoni | |
| Wortmannin | - |
Schistosoma mansoni | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70500 | - |
theoretical | Schistosoma mansoni |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Schistosoma mansoni | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | Q5UES2 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Schistosoma mansoni |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ cell | germinal cell of schistosome | Schistosoma mansoni | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Schistosoma mansoni | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Plk1 | - |
Schistosoma mansoni |
| Polo-like kinase 1 | - |
Schistosoma mansoni |
| SmPlk1 | - |
Schistosoma mansoni |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Schistosoma mansoni | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Schistosoma mansoni | theoretical | - |
9.13 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | conserved function in mitotic processes | Schistosoma mansoni |
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Release 2023.1 (January 2023)
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