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Literature summary for 2.7.11.21 extracted from

  • Yoshida, S.; Kono, K.; Lowery, D.M.; Bartolini, S.; Yaffe, M.B.; Ohya, Y.; Pellman, D.
    Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis (2006), Science, 313, 108-111.
    View publication on PubMed
Search for more literature for 2.7.11.21

Application

Application Comment Organism
additional information Cdc5 is required to establish contractile actin ring assembly and to maintain it. Cdc5 controls the targeting and activation of Rho1 at the division site via Rho1 guanine nucleotide exchange factors Tus1 and Rom2 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information mutants lacking Cdc5, contractile actin ring assembly is impaired Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Rom2 Saccharomyces cerevisiae bound by the polo-box domain of Cdc5 ADP + phosphorylated Rom2
-
 ?
ATP + Tus1 Saccharomyces cerevisiae bound by the polo-box domain of Cdc5 ADP + phosphorylated Tus1
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 strains isogenic to BY4741
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Bem3 bound by the polo-box domain of Cdc5 Saccharomyces cerevisiae ADP + phosphorylated Bem3
-
 ?
ATP + Ecm25 bound by the polo-box domain of Cdc5 Saccharomyces cerevisiae ADP + phosphorylated Ecm25
-
 ?
ATP + Rom2 bound by the polo-box domain of Cdc5 Saccharomyces cerevisiae ADP + phosphorylated Rom2
-
 ?
ATP + Sac7 bound by the polo-box domain of Cdc5 Saccharomyces cerevisiae ADP + phosphorylated Sac7
-
 ?
ATP + Tus1 bound by the polo-box domain of Cdc5 Saccharomyces cerevisiae ADP + phosphorylated Tus1
-
 ?

Synonyms

Synonyms Comment Organism
Cdc5
-
 Saccharomyces cerevisiae
polo-like kinase
-
 Saccharomyces cerevisiae