Literature summary for 2.7.11.21 extracted from

Darieva, Z.; Bulmer, R.; Pic-Taylor, A.; Doris, K.S.; Geymonat, M.; Sedgwick, S.G.; Morgan, B.A.; Sharrocks, A.D.
Polo kinase controls cell-cycle-dependent transcription by targeting a coactivator protein (2006), Nature, 444, 494-498.

Search for more literature for 2.7.11.21

Application

Application	Comment	Organism
additional information	Cdc5p is required for the production of key mitotic regulators	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
HA-epitope-tagged Cdc5p expressed in FKH2 and fkh2delta strains	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Fkh2p	Fkh2p is only poorly phosphorylated by Cdc5p, Fkh2p has a function in nucleating the formation of a Fkh2p-Ndd1p-Cdc5p complex on CLB2 cluster promoters, and the subsequent Cdc5p-dependent phosphorylation of Ndd1p at Ser 85	Saccharomyces cerevisiae	ADP + phosphorylated Fkh2p	-	?
ATP + Ndd1p	phosphorylation of Ser 85, phosphorylation is required for the normal temporal expression of cell-cycle-regulated genes such as CLB2 and SWI5 in G2/M phase	Saccharomyces cerevisiae	ADP + phosphorylated Ndd1p	-	?

Synonyms

Synonyms	Comment	Organism
Cdc5p	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)