Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-[[4-(1H-benzimidazol-5-ylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzene-1,2-diyl)dicyanamide | - |
Homo sapiens | |
1-[3-[(5,6,7-trimethyl-2-phenyl-7H-cyclopenta[d]pyrimidin-4-yl)amino]propyl]pyrrolidin-2-one | - |
Homo sapiens | |
2-chloro-4-hydroxy-5-(3-phenoxyphenyl)-7,7a-dihydrothieno[2,3-b]pyridin-6(3aH)-one | 21% inhibition at 0.05 mM | Homo sapiens | |
3-([4-[(5-methoxy-2-methylphenyl)amino]pyrimidin-2-yl]amino)benzamide | 36% inhibition at 0.05 mM | Homo sapiens | |
3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-3,4-dihydroquinazolin-2(1H)-one | 48% inhibition at 0.05 mM | Homo sapiens | |
4-(4-amino-2-methylphenyl)-N-methylpyridin-2-amine | 75% inhibition at 0.05 mM | Homo sapiens | |
A-484954 | - |
Homo sapiens | |
N,N'-bis(2-methylphenyl)quinazoline-2,4-diamine | - |
Homo sapiens | |
N-(2,6-dimethylphenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methoxyphenyl]urea | - |
Homo sapiens | |
N-(2,6-dimethylphenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]urea | 8.7% inhibition at 0.02 mM | Homo sapiens | |
N-(2-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]urea | 53.6% inhibition at 0.02 mM | Homo sapiens | |
N-(2-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methoxyphenyl]urea | 6.4% inhibition at 0.02 mM | Homo sapiens | |
N-(2-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]urea | 21.7% inhibition at 0.02 mM | Homo sapiens | |
N-(2-hydroxyethyl)-1-(4-[(E)-[(7-hydroxy-6H-[1,3]thiazolo[5,4-e]indol-8-yl)methylidene]amino]phenyl)methanesulfonamide | - |
Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]urea | 82.7% inhibition at 0.02 mM | Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-fluorophenyl]urea | 52.5% inhibition at 0.02 mM | Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methoxyphenyl]urea | 30.6% inhibition at 0.02 mM | Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]urea | 73.4% inhibition at 0.02 mM | Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-(propylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]urea | 38.2% inhibition at 0.02 mM | Homo sapiens | |
N-(3-chlorophenyl)-N'-[4-[2-[(cyclopropylmethyl)amino]pyridin-4-yl]-3-(trifluoromethyl)phenyl]urea | 27.8% inhibition at 0.02 mM | Homo sapiens | |
N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]urea | 37.2% inhibition at 0.02 mM | Homo sapiens | |
N-[4-([4-(azetidin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl]sulfanyl)phenyl]propanamide | - |
Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-(4-methoxyphenyl)urea | 51.3% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-(4-methylphenyl)urea | 37.9% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-[4-(naphthalen-2-yl)phenyl]urea | 44% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 76.3% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-fluorophenyl]-N'-(4-methoxyphenyl)urea | 34.4% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-fluorophenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 41.2% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methoxyphenyl]-N'-(4-methoxyphenyl)urea | 9.0% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methoxyphenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 34.6% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]-N'-(4-methoxyphenyl)urea | 33.4% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]-N'-(4-methylphenyl)urea | 35.4% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]-N'-[4-(naphthalen-2-yl)phenyl]urea | - |
Homo sapiens | |
N-[4-[2-(ethylamino)pyridin-4-yl]-3-methylphenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 55.3% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-(propylamino)pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 33.3% inhibition at 0.02 mM | Homo sapiens | |
N-[4-[2-[(cyclopropylmethyl)amino]pyridin-4-yl]-3-(trifluoromethyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea | 15.1% inhibition at 0.02 mM | Homo sapiens | |
N2,N2-dimethyl-6-[[(2-phenoxyethyl)amino]methyl]-N4-[(1S)-1-phenylethyl]-1,3,5-triazine-2,4-diamine | - |
Homo sapiens | |
NH125 | 1-benzyl-3-cetyl-2-methylimidazolium iodide | Homo sapiens | |
rottlerin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Homo sapiens | the enzyme phosphorylates elongation factor 2 at Ser56 and Thr58 | ADP + [elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00418 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
BT-483 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | the enzyme phosphorylates elongation factor 2 at Ser56 and Thr58 | Homo sapiens | ADP + [elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase-III | - |
Homo sapiens |
CaMK-III | - |
Homo sapiens |
eEF2K | - |
Homo sapiens |
eukaryotic elongation factor 2 kinase | - |
Homo sapiens |