Literature summary for 2.7.11.20 extracted from

Moore, C.E.; Wang, X.; Xie, J.; Pickford, J.; Barron, J.; Regufe da Mota, S.; Versele, M.; Proud, C.G.
Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy (2016), Cell. Signal., 28, 284-293 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
JAN-452	less potent inhibitor	Homo sapiens
JAN-849	potent inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	Homo sapiens	-	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00418	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	-	Homo sapiens	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
eEF2K	-	Homo sapiens
eukaryotic elongation factor 2 kinase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	inhibiting the enzyme or knocking down its expression renders cancer cells sensitive to death under nutrient-starved conditions	Homo sapiens
physiological function	the enzyme is cytoprotective for cells faced with glucose starvation. The enzyme promotes cell survival by inhibiting protein synthesis without inducing autophagy. The enzyme makes a substantial contribution to the cytoprotective effect of mammalian target of rapamycin complex 1 inhibition	Homo sapiens

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Release 2023.1 (January 2023)