Literature summary for 2.7.11.20 extracted from

Will, N.; Piserchio, A.; Snyder, I.; Ferguson, S.B.; Giles, D.H.; Dalby, K.N.; Ghose, R.
Structure of the C-terminal helical repeat domain of eukaryotic elongation factor 2 kinase (2016), Biochemistry, 55, 5377-5386 .

Search for more literature for 2.7.11.20

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	-	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
wild type and mutants Y712A/Y713A and E717A of the C-terminal enzyme fragment eEF-2K627-725 are expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E717A	the mutation in the C-terminal fragment of the enzyme reduces elongation factor 2 phosphorylation activity	Homo sapiens
Y712A	the mutation in the C-terminal fragment of the enzyme reduces elongation factor 2 phosphorylation activity	Homo sapiens
Y712A/Y713A	the mutations in the C-terminal fragment of the enzyme abolish elongation factor 2 phosphorylation activity	Homo sapiens
Y713A	the mutation in the C-terminal fragment of the enzyme reduces elongation factor 2 phosphorylation activity	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	activates	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	Homo sapiens	-	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00418	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography, and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	-	Homo sapiens	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
EEF-2K	-	Homo sapiens
eukaryotic elongation factor 2 kinase	-	Homo sapiens

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Release 2023.1 (January 2023)