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Literature summary for 2.7.11.20 extracted from

  • Kameshima, S.; Okada, M.; Yamawaki, H.
    Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts (2019), Apoptosis, 24, 359-368 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic elongation factor 2] Rattus norvegicus
-
 ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P70531
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyoblast
-
 Rattus norvegicus
-
H9c2 cell
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic elongation factor 2]
-
 Rattus norvegicus ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Rattus norvegicus
eEF2K
-
 Rattus norvegicus
eukaryotic elongation factor 2 kinase
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction enzyme gene knockdown significantly augments glucose deprivation-induced cleavage of caspase-3 and apoptotic nuclear condensation. In contrast, enzyme gene knockdown significantly inhibits glucose deprivation-induced increase of microtubule-associated protein 1 light chain 3-II to -I ratio and autophagosome formation. Enzyme gene knockdown significantly inhibits GD-induced phosphorylation of adenosine monophosphate-activated protein kinase alpha and its downstream substrate, unc-51 like autophagy activating kinase 1 Rattus norvegicus
physiological function the enzyme mediates the inhibition of cardiomyocyte death under glucose deprivation condition Rattus norvegicus