Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | calcium-calmodulin-dependent enzyme | Gallus gallus | |
additional information | high potassium-evoked Ca2+ elevation enhances phosphorylation of eEF2 in growth cones, overview | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation by p70-S6 kinase inhibits EF2K, Ca2+ decreases the phosphorylation of the enzyme | Gallus gallus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcium-calmodulin-dependent enzyme, calcium also decreases the level of phosphorylated p70-S6 kinase, a kinase known to inhibit EF2K | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | Gallus gallus | eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation by p70-S6 kinase inhibits EF2K, Ca2+ decreases the phosphorylation of the enzyme | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | DRG neurons | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation elongation factor 2] | phosphorylation at Thr56 | Gallus gallus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? | |
ATP + [eukaryotic translation elongation factor 2] | eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview | Gallus gallus | ADP + [eukaryotic translation elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Gallus gallus |
EF2K | - |
Gallus gallus |
More | formerly CaMKIII | Gallus gallus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Gallus gallus |