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Literature summary for 2.7.11.20 extracted from

  • Sans, M.D.; Xie, Q.; Williams, J.A.
    Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini (2004), Biochem. Biophys. Res. Commun., 319, 144-151.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
calyculin reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin Rattus norvegicus
additional information no effect by CPT-cAMP and A23187 Rattus norvegicus
PD98059 reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin Rattus norvegicus
Rapamycin reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin Rattus norvegicus
SB202190 reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
bombesin a secretagogue, increases elongation rates, and decreases elongation factor 2 phosphorylation Rattus norvegicus
Carbachol a secretagogue, increases elongation rates, and decreases elongation factor 2 phosphorylation Rattus norvegicus
Cholecystokinin a secretagogue, increases elongation rates, increases phosphorylation of eEF2 kinase, and decreases elongation factor 2 phosphorylation reversed by rapamycin, PD98059, calyculin, or SB202190 Rattus norvegicus
additional information no effect by CPT-cAMP and A23187 Rattus norvegicus
phorbol ester PMA
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 2] Rattus norvegicus elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview ADP + [elongation factor 2]phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Ser366 inhibits the enzyme, mediated by cholecystokinin Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Rattus norvegicus
-
pancreatic acinar cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 2] elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview Rattus norvegicus ADP + [elongation factor 2]phosphate
-
?
ATP + [elongation factor 2] phosphorylation at Thr56 Rattus norvegicus ADP + [elongation factor 2]phosphate
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus