Activating Compound | Comment | Organism | Structure |
---|---|---|---|
calyculin | reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin | Rattus norvegicus | |
additional information | no effect by CPT-cAMP and A23187 | Rattus norvegicus | |
PD98059 | reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin | Rattus norvegicus | |
Rapamycin | reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin | Rattus norvegicus | |
SB202190 | reverses activation of the elongation factor 2 by dephosphorylation through cholecystokinin | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bombesin | a secretagogue, increases elongation rates, and decreases elongation factor 2 phosphorylation | Rattus norvegicus | |
Carbachol | a secretagogue, increases elongation rates, and decreases elongation factor 2 phosphorylation | Rattus norvegicus | |
Cholecystokinin | a secretagogue, increases elongation rates, increases phosphorylation of eEF2 kinase, and decreases elongation factor 2 phosphorylation reversed by rapamycin, PD98059, calyculin, or SB202190 | Rattus norvegicus | |
additional information | no effect by CPT-cAMP and A23187 | Rattus norvegicus | |
phorbol ester PMA | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Rattus norvegicus | elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview | ADP + [elongation factor 2]phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Ser366 inhibits the enzyme, mediated by cholecystokinin | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Rattus norvegicus | - |
pancreatic acinar cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview | Rattus norvegicus | ADP + [elongation factor 2]phosphate | - |
? | |
ATP + [elongation factor 2] | phosphorylation at Thr56 | Rattus norvegicus | ADP + [elongation factor 2]phosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |