Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-oxoisopentanoate | - |
Bos taurus | |
acetyl-CoA | - |
Bos taurus | |
NADH | activation, in the presence of NH4+ | Bos taurus | |
NADH | activation, in the presence of K+ | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | inhibition only in the presence of monovalent cations | Bos taurus | |
Disulfides | thiols reverse | Bos taurus | |
DTNB | - |
Bos taurus | |
NEM | - |
Bos taurus | |
pyruvate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
Mg2+ | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | inner membrane matrix compartment | Bos taurus | 5739 | - |
mitochondrion | tightly bound to dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex | Bos taurus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus | |
Mn2+ | requirement | Bos taurus | |
Mn2+ | can replace Mg2+ to some extent | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
48000 | - |
1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
100000 | - |
- |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
kidney, from highly purifed pyruvate dehydrogenase-complex | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Bos taurus | - |
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | highly specific for the substrate | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | phosphorylation sites are 3 Ser-residues in the alpha-subunit, i.e. E1, MW 41000, of pyruvate dehydrogenase | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
additional information | no activity with glycogen synthase a and rabbit skeletal muscle phosphorylase b | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
More | kinase activity resides in alpha-subunit | Bos taurus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.533 | - |
ATP | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Bos taurus |